Recently, Apple released an update for Mac users that some say can cause problems for those needing Rosetta. See http://reviews.cnet.com/8301-13727_7-57371552-263/apple-fixes-rosetta-pr...
I experienced a weird problem that may or may not be related. The other day several applications became partially disabled. I couldn't use the commands SAVE AS, OPEN, or PRINT with Word (Office 2004), PowerPoint, Quicken 2007, TurboTax 2011, and AppleWorks. Using Page Setup with those programs would pop up a window that was essentially blank. Once any of the offending commands were given, the applications would either freeze or crash. Other applications like Adobe Reader, Pages, and Safari were unaffected. I ran DiskUtility to repair permissions and reinstalled the OS (Snow Leopard 10.6). None of that fixed the issue.
I took my problem to the Genius Bar at the Apple Store at Town Square. The techie told me to try uninstalling and reinstalling my printers. If that didn't work he recommended erasing my hard drive, reinstalling the OS, and manually moving my files from backup to the cleaned hard drive. That's where I ended up. Things seem to be humming along now.
Heads up, however. If you haven't done a thorough backup (or two) of all your files, if you don't have discs and especially key codes for your applications, get that done. You never know when things will come crashing down and you have to reassemble your computing life.